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In addition, it will be interesting to distinguish between UPS-dependent and UPS-independent anticancer activities of copper complexes

A key factor in PAH is the hyperproliferation and anti-apoptosis of pulmonary artery smooth muscle cells (PASMCs), contributing to vascular remodeling

doi: 10.1172/JCI180904

Furthermore, 1060% of patients receiving OXA-based chemotherapy have abnormal liver function which can cause chemotherapy delays and necessitate dose reduction, as well as increase the incidence of irregular events during chemotherapy (6,8)