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Psychiatry 162 WangX.SimpkinsJ

Despite its importance, B12 deficiency is remarkably common particularly among vegetarians, older adults, individuals with digestive conditions, and anyone whose body has difficulty absorbing this vitamin from food or oral supplements

Int J Mol Sci 23(10):5744

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Previously, it was shown by experiments with purified proteins that proteins like hemoglobin (Grune et al, 2003), calmodulin (Ferrington et al, 2001) and ferritin (Shringarpure et al, 2003) that are not susceptible to degradation by the 20S proteasome under basal conditions, become 20S substrates following oxidative stress

Interestingly, inhibition of the binding to IKK by using a peptide inhibitor reduced NF-B activity and thereby senescence in progeroid mice (88)