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(3) C A CaldernOspina and M O NavaMesa (2019) B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin CNS Neuroscience Therapy, 2019 Sep 6, Volume 26 (Issue 1), Pages 513

Therefore the economic literature search identified 2 relevant articles

Inadequate absorption This is a common cause of B12 deficiency as the uptake mechanism is surprisingly complex

A combination of treatment approaches can offer better outcomes than a single substance or therapy [11]

The symptom relief should last 3-6 months, and sometimes as long as 12 months

When the FDA restricts a compound that patients want and doctors believe in, those patients dont stop seeking it