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However, the clinical study did not acomplish the main goal of a Phase IIb study by not showing differences over the placebo treatment under FDA current guidelines 4

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Accordingly, we advocate that preclinical pipelines include: (i) paired SCC and AC in vitro clonogenic and DNA-damage assays with hydrogel-released radiosensitizers

Pekna has been supported by grants from Swedish Research Council (2024-02814), the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement (1005387), The Swedish Brain Foundation (FO2023-0157) and The Swedish Stroke Foundation

Acknowledgements The authors acknowledge financial support from the National Natural Science Foundation of China (grant no