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172 Pretreatment with the KD is associated with a reduction of pro-inflammatory cytokines, such as IL-1 and tumor necrosis factor alpha (TNF-), which are induced by lipopolysaccharide injection, thereby suggesting that KD has anti-inflammatory properties

In addition, the circadian-related microRNAs, mir-132 (Davis et al., 2010)

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This multi-dimensional activity highlights its potential as both a therapeutic target and a diagnostic biomarker

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IL-1beta is a key cytokine that induces trypsin upregulation in the influenza virus-cytokine-trypsin cycle