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doi:10.1007/s11739-021-02688-x

Jones KA

Second, even taken at face value, an assay-specific potency ratio is not a measure of whole-organism effect: it does not mean Dihexa is millions of times more effective in a living brain, where absorption, distribution, and signaling context all differ

For instance, N-Acetyl-Nle-Tyr-Ile-His had a half-life of 115 7.6 min, D-Nle-Tyr-Ile showed 225 23.7 min, and GABA-Tyr-Ile exhibited a remarkable 946 234 min