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doi: 10.3389/fcimb.2024.1387497 Received 17 February 2024 Accepted 15 March 2024 Published 04 April 2024 Volume 14 - 2024 Edited by Ibrahim Bitar, Charles University, Czechia Reviewed by Hamid Solgi, Isfahan University of Medical Sciences, Iran Dariush Shokri, Isfahan University of Medical Sciences, Iran Updates Copyright 2024 Nasrollahian, Graham and Halaji

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After entering the cell, cystine is oxidized to cysteine, which is ultimately synthesized into glutathione (GSH) by glutathione synthetase and glutamate-cysteine ligase