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Notably, the levels of DNMTs and TETs are abnormal in the retina and its vascular system in diabetic rats, suggesting that DNA methylation may play a role in the pathogenesis of DR (Kowluru et al., 2016

Theranostics 10 , 41344149 (2020)

As discussed later in this review, this mediator is the transcription factor peroxisome proliferator-activated receptor coactivator 1 (PGC-1 ), and its role in simultaneously inducing bioenergetic and antioxidant adaptations has been demonstrated in several experimental models of mtROS production, including treatments with paraquat and H 2 O 2