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(PubMed) Karp DD, Lee SJ, Keller SM, et al

The occluded structure of ABCB7 in the ATP-bound, pre-hydrolytic state We captured the occluded conformation of human ABCB7 (E634Q mutant) in the presence of CoPP and Mg 2+ /ATP

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It further discusses the challenges in this emerging field and proposes future research directions, thereby facilitating the clinical translation of PTT-based strategies in AD treatment