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Human repeat-insult patch testing showed no skin irritation or sensitization even at 100%

Over the past 15 years, technological breakthroughs have shown that CFE reactions are linearly scalable between the L and 100 L scales, enabling high yields of proteins

Huan Cheng, Z

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for example: aryl and vinyl sulfonyl chlorides were considerably more productive than aliphatic sulfonyl chlorides (presumably due to rapid hydrolysis of the latter in aqueous mixtures), and sterically more hindered aldehydes and carboxylic acids tended to be less reactive

TabeUe 2The reaction is continued for Ibis for 4 hours, preferably 2 hours