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Semaglutide (Wegovy) and tirzepatide (Zepbound) have demonstrated significant average weight loss14.9% and 20.9% of body weight at approximately one year, respectively

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

Avoid complete immobilization unless specifically indicated

Professional liability considerations may differ from those associated with FDA-approved medications, and providers should maintain comprehensive documentation of treatment rationale and patient consent

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As demonstrated in the Examples below, the HGF mimics can inhibit the HGF/Met system, and therefore can be used as anti-cancer agents