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The development of nanomedicines for commercial use is difficult due to challenges in clinical trials

L-arginine can induce a shift from glycolysis to OXPHOS in effector T cells, enhancing their anti-tumor immune effects

The excised tissue specimens were diagnosed as benign breast disease or breast cancer by more than 2 physicians from the Department of Pathology of Yunnan Cancer Hospital

Dan Dunn et al., 2015)

10.1016/j.jid.2022.01.005 47 DavidE.UngarB.Renert-YuvalY.FacherisP.Del DucaE.Guttman-YasskyE

Similarly, oral acute toxicity tests at 3,000 mg/kg and 5,000 mg/kg resulted in no deaths, suggesting an LD 50 greater than 5,000 mg/kg, classifying it as practically non-toxic and safe (709)