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Yang H, Cao K

Common side effects include: Weight gain Nausea or vomiting Diarrhea Asthma or breathing problems Hair whitening or loss Skin rashes Hives or allergic reactions Rare severe reactions like toxic epidermal necrolysis or Steven-Johnson syndrome (with higher doses) Always consult with a qualified practitioner to minimize the risk of side effects

185 Estrogen taken orally undergoes transformation in the liver prior to reaching the systemic bloodstream, a phenomenon known as first pass. The by-products of estrogen metabolism in the liver have more negative side effects, particularly cardiovascular effects, than estrogen

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Both groups then received an injection of fentanyl (75 g/kg, IV) and BT was recorded 5, 10, 15, 20, 25 and 30 min later

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