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In a phase 2 Trial, a randomized, double-blind, placebo-controlled clinical trial involving 60 people with PD

10.1016/j.bbamcr.2017.03.004 44

At the end of the study, the results showed significant improvements in plasma insulin and insulin resistance in this group compared to the placebo arm 43

The cysteine is then converted to glutathione

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Our in vivo findings showed that both TFEB and TFE3 co-localize with muHTT aggregates in the striatum and cortex of HD mouse models expressing 190 CAGs