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May 12, 2011. Public Advisory

Springer International Publishing, Cham, pp 173184 Acknowledgements We express our sincere gratitude to MSc

They drive intricate crosstalk with immune populations, particularly macrophages, via inflammatory mediators and extracellular vesicles (EVs), thereby amplifying the intrarenal inflammatory response

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Combining MDSC checkpoint blockade with immune checkpoint inhibitors (such as PD-1/PD-L1 blockade), adaptive cellular therapies (e.g., CAR-T and CAR-NK cells) and multiple MDSC checkpoints targeting strategies could create synergistic therapeutic strategies to enhance anti-tumor immunity while mitigating the negative impact of MDSCs

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