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Even though familial cases comprise only a minor subset of the overall PD pool, examining PD-related monogenic mutations is a valuable method of understanding disease pathogenesis and cell death which may have implications for studying the disease at large

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Maintenance of methylation is critically dependent upon MethylCo(III)B12 and the enzyme methionine synthase (MTR) The methylation cycle is also dependent upon two enzymes that require functional B2 sufficiency, MTHFR and MTRR Maintenance of functional vitamin B12 requires functional B2 deficiency, Lack of functional B2 in leads to functional B12 deficiency and a reduction in methylation activities Functional Vitamin B2 deficiency can lead to functional B6 deficiency, exacerbating functional B12 deficiency Functional Vitamin B2 deficiency and associated functional B12 deficiency, can lead to functional folate deficiency