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In addition, knockdown of OTUB1 diminished the HMW SLC7A11 complex formation and the overall levels of SLC7A11 and GSH in H522 cells (Fig

Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

c , Relative viability (survival of compound-treated cells divided by survival of vehicle-treated cells) of IMR5/75 cell line after treatment with RSL-3 in the presence or absence of MYC inhibitor (10058-F4) ( n = 4 samples, experiment replicated 3 times) and d , Response to GPX4 inhibitors (RSL-3, ML-210) (CTRPv2 database 54 )

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Endocrinology 148:441451 Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (igf-1) and type 1 IGF receptor (Igf1r)