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Here, we employ a multicellular HLO microfluidic chip platform as a model of DILI that is composed of ~60% hepatocytes, ~20-30% hepatic stellate cells (HSCs), and 0.5 and an FDR 1.45 (64.0% vs 40.0%, p 1 (63.0% vs 37.0%, p 2.67 (57.0% vs 43.0%, p 1 liver biopsy at our institution between 1996 and 2015 and who had HCV viremia at the time of all biopsies were selected for study

(2009) 5:e1000561

In addition, all drugs were well tolerated, no severe adverse reactions occurred

Each culture (with two biological replicate cultures for both the selective and non-selective conditions) was grown to full density (56 doublings) while shaking at 30 C