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There was a significant time effect as the post-exercise assessment produced greater thigh girth measurements with exercise across all study participants

In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins

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[12] had some methodological points of criticism