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Oral Dis 16:488495

10.1016/s0306-4522(02)00123-9 35 MolteniR.WuA.VaynmanS.YingZ.BarnardR

doi: 10.2105/AJPH.2017.304032

By promoting both fibroblast proliferation and collagen biosynthesis, AHK-Cu may potentially influence a dual pathway of structural maintenance that involves both sustaining the population of matrix-producing cells while simultaneously accelerating the deposition of new collagen fibers

Despite the number and importance of such enzymes to cellular metabolism, few studies have been conducted to better understand the effects of MTX on cellular metabolic homeostasis or find metabolic fragilities that could be exploited clinically