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doi: 10.1002/mpo.10188 231 WuXZhangYPeiZChenSYangXChenYet al

J Biol Chem 267: 1821018217

Bioactive substances present in different mushroom species have been ascribed to both direct and indirect mechanisms of influence on neurobehavior, and here we support the recognition of mushroom nutrition as an influential dietary element in prevention and management of some neurologic concerns

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Hesperidin, at high doses, inhibits CYP1B1 and also CYP3a4

A 900 L aliquot of hypo-osmotic solution (prepared by dissolving 0.9 g fructose (Solarbio, #F8100, China) and 0.49 g sodium citrate (Solarbio, #S6100, China) in 100 mL deionized water) was pre-warmed at 37 C for 30 min in a constant temperature water bath