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(2) the APL Revolution (1970s-2000), marked by the identification of the promyelocytic leukemia protein (PML)-retinoic acid receptor alpha (RAR) fusion protein as a specific molecular target, elucidation of the small ubiquitin-related modifier (SUMO)ylation-dependent degradation mechanism, and subsequent Food and Drug Administration (FDA) approval, establishing a precision paradigm

J Pharmacol Sci 108:22738, PMID: 19008644 Lertratanangkoon K, Wu CJ, Savaraj N, Thomas ML (1997) Alterations of DNA methylation by glutathione depletion