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Description

+ (c) (SHREL TO USA, MESF) Potential for Collateral Damage

In the early stage of cytotoxicity (upper panel), lymphocytes (identified by electron-dense nuclei and a narrow rim of cytoplasm) are closely apposed to myofibroblast-like cells (spindle-shaped with elliptical nuclei and abundant cytoplasm containing rough endoplasmic reticulum, mitochondria, and an actin belt)

doi: 10.1007/s00277-012-1594-z 145 AngelucciESantiniVDi TucciAAQuaresminiGFinelliCVolpeAet al

There is clear evidence to suggest a role for OATP-mediated uptake of unbound HMCD, which we and others have shown in vitro in the absence of albumin (71, 74)