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We have shown previously that sirtuins SIRT1 and SIRT3 have anti-fibrotic function, and their decreased tissue expression observed in skin biopsies from SSc patients, might directly contribute to the persistence of fibrosis 28,29

N Engl J Med 2011, 364: 8991

Monthly Visits During your monthly (every 4 weeks) medical weight loss appointment you will weigh in, your provider will conduct a dietary review, lifestyle changes review, exercise review, and medication adjustments