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Findings revealed persistent metabolic consequences of maternal hyperglycemia on long-term offspring glucose homeostasis, notably extending to glycemic levels below current GDM diagnostic thresholds

1, Table 1 and Methods

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This can occur due to a genetic predisposition (vitamin B12 deficiency anemia is more prevalent in people with a northern European heritage or with a family history of this condition)

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To test LaccID in a similar manner, we created an ER-targeted construct by appending a KDEL ER retention sequence and prepared analogous constructs for APEX2 and HRP for comparison