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Degradation of HIF alpha prevents formation of the HIF heterodimers

Coney AM, Marshall JM

IGF-1 LR3 carries a 13-amino-acid N-terminal extension and an arginine substitution at position 3, which together reduce IGFBP binding while preserving IGF-1R agonist activity

Both lycopene and epigallocatechin-3-gallate (EGCG) have been shown to mitigate the neurotoxic effects induced by 3-NP by improving memory performance and restoring glutathione levels, which are crucial for antioxidant defence