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This indicates that KRAS (G12C) is still sensitive to GEF (such as SOS1) regulation

During oxidative stress conditions characterized by Fenton reaction activity, GPX4 catalyzes the critical conversion of toxic lipid hydroperoxides (L-OOH) into their non-toxic alcohol derivatives (L-OH), thereby interrupting the chain reaction of lipid peroxidation [64-66]

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doi:10.1016/j.urology.2016.07.001 Ilic, Dragan et al

Four of the 36 patients tested experienced mild adverse events such as blepharitis, keratitis, hyperemia, and ocular irritation, all of which resolved within 72 h

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