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For the vascular side, GHK-Cu promotes angiogenesis through VEGF and bFGF expression, improves blood vessel integrity, and supports microcirculation

Although years of continuous research have revealed a variety of possible pathogeneses for the development of NP and proposed many treatment methods, most people have ignored the importance of the opioid system in NP due to the low therapeutic efficacy, complex side effects, and high analgesic tolerance of opioids [10,11,12,13,14]

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Ultimately, this FOXO4-DRI-mediated mechanism selectively eliminates senescent endothelial cells, which in turn attenuates vascular inflammation and improves endothelial-dependent vasodilation, conferring a significant protective effect on vascular function

For patients who prefer nasal application