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SIRT1 upregulates the expression of NRF2 target antioxidant genes, including mitochondrial antioxidant manganese superoxide dismutase (MnSOD), catalase, heme oxygenase-1 (HO-1), and glutathione (40, 41)

The most prominent metabolic process carried out by mitochondria is oxidative phosphorylation (OXPHOS) to generate ATP

Not only this but stimulating lipolysis and inhibiting lipogenesis means AOD9604 can theoretically play a major role in decreasing the chances of hypercholesterolemia

Enteric solute sensors are said to modulate the activities of dietary Na + , K + , and phosphate

Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): Implication of macrophages resident in the AT

Proc Natl Acad Sci USA 106:1472814733 Coen M, Lenz EM, Nicholson JK, Wilson ID, Pognan F, Lindon JC (2003) An Integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy