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MN-E: ~ 92%

Additionally, macrophages exhibit synergistic characteristics of dynamic phenotypic conversion and functional remodeling in response to DAMPs: during the acute injury phase, DAMPs (such as high-mobility group box protein B1 and adenosine triphosphate) activate the Toll-like receptor 4/P2X7 receptor pathway, which in turn activates the NF-B and NLRP3 inflammasome, driving macrophages toward M1 polarization and the secretion of pro-inflammatory factors such as interleukin-1(IL-1) and tumor necrosis factor- (TNF-), thereby establishing an efficient pathogen clearance mechanism (Gong et al., 2020) (86)

As this jet passed above the warm surface waters of the North Atlantic and the Mediterranean, especially along the Gulf Stream and Tyrrhenian outflows, it encountered and entrained substantial moisture, which it subsequently advected towards Southern Italy

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10.5334/aogh.4163 [PMC free article: PMC10289045] [PubMed: 37362827] [CrossRef] Gold EB, Gordis L, Diener MD, Seltser R, Boitnott JK, Bynum TE, et al