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2023;270(6):2890-2907 Johansson H

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2.4 Oxidative stress markers Numerous studies have implicated oxidative stress in IS pathophysiology, arising from ischemia-induced mitochondrial dysfunction, molecular damage, excitotoxicity, and inflammation (67)

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Although both compounds are easily assayed through targeted testing, ADSL deficiency is easily identified on untargeted metabolomics by strikingly high levels of S-Ado in both plasma and CSF (78)