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References 1 AirakiM.Snchez-MorenoL.LeterrierM.BarrosoJ

doi:10.1016/j.placenta.2010.02.011

2016;11:e0166388

Sixthly, the pathogenic mechanisms of diseases are exceedingly complex, involving genetic factors, environmental influences, and numerous unknown variables

The production of ROS is mainly secondary to enzymatic reactions involved in the respiratory chain, activity of cytochrome p-450, synthesis of prostaglandins and phagocytosis (Pizzino et al., 2017)

In the colon, only a few macrophages were observed in the submucosal layer on the 3rd day after DSS treatment, but on the 5th day, many macrophages were observed in the mucosal and the submucosal layer where the colon plicae had collapsed (Fig