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Moreover, these inactivated vaccines all use Alum as the adjuvant, which is generally a poor stimulator of T cell responses (Table 1)

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Overall, polyphenols from various plants, algae, and natural sources possess notable anti-inflammatory potential and contribute to the prevention and management of chronic inflammatory diseases (287, 288)

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These observations support the notion that HSC aging initiates maladaptive trained immunity to drive aging-associated inflammation