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Functions of other than BRD4 ET and MLL4 PHD2/3 domains in BRD4 and MLL3/4, such as acetyllysine binding activity of bromodomains of BRD4 18,19,20 and TET3- and H4K16ac-binding activities of MLL3/4 40,41,42,43 may also contribute

The intracellular GSH is decreased with the increased CCF concentration, accompanied by increased tumor cell apoptosis (Figure 5B), which demonstrates the antitumor effect of GSH-promoted CDT