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If such a vicious cycle of glutamate excitotoxicity, oxidative stress, and mitochondrial dysfunction does indeed underpin ME/CFS pathology, it may not be clear where exactly the root problem lies

Biol Plant 57:555558 Furlan A, Bianucci E, Tordable MC, Castro S, Dietz K (2014) Antioxidant enzyme activities and gene expression patterns in peanut nodules during a drought and rehydration cycle