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Therefore, hyperammonemic patients present potentially life-threatening neuropsychiatric symptoms, whose severity is related with the hyperammonemia magnitude and duration, as well as the brain maturation stage

The most common AEs reported for both cohorts included headache responsive to analgesia, tiredness, and dyspnea (Table 1)

( b-e ) Body weight ( b ), circulating glucose ( c ), BHB ( d ) and insulin ( e ) in male and female mice fed CD, HFD, or KD over the experimental timeline