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This suggests a viral strategy of upregulating purine metabolism at the post-translational level to coincide with the shutting off of the majority of host proteins at translation levels

Glucosylation of Rho proteins by Clostridium difficile toxin B

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These results have been replicated multiple times

Rath et al., 2020)

Additionally, lactate produced by colorectal cancer can induce M2 macrophage polarization by activating the AKT-ERK pathway