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Alin P, Danielson UH, Mannervik B

NADPH-FSP1-CoQ10 pathway In the study of the ferroptosis-resistant cell line MCF7, the researchers screened the complementary gene for GPX4 deletion and found the apoptosis-inducing factor mitochondrial 2 (AIFM2) gene, which was initially found to induce apoptosis, and the researchers named it ferroptosis suppressor protein 1 (FSP1) [22]

doi: 10.3109/03602532.2011.602688 51 JollowD

Experimental evidence points to IKK/NF-B signaling as a central mediator, while PI3K/Akt and MAP kinase activation leads to serine/threonine modifications of insulin receptor substrates (IRSs), ultimately disrupting glucose homeostasis (386)

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