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Acknowledgements The authors would like to acknowledge all members of the State Key Laboratory of Respiratory Disease at Guangzhou Medical University for their invaluable support and stimulating discussions

(2) feedback inhibitory effects of GSH on glutamate cysteine ligase (GCL) activity (the first biosynthetic enzyme), which is regulated by the availability of cysteine (Jones, Direct delivery of GCC to the brain has been previously reported to protect against cellular depletion of GSH in the brain using the Buthionine sulfoximine (BSO) model of depletion and increase GSH levels in the pre-perturbed model (Pileblad and Magnusson, Previous studies such as those by Dringen et al

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doi: 10.1016/j.cbpa.2017.07.006