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For all other participants, Table 2 and Figure 2a shows the level of urinary excretion of toxic metals (normalized per gram creatinine) at baseline (beginning of Phase 1, before taking any DMSA), and after the first and 9 th doses of DMSA in the Phase 1 challenge round

As a small-molecule NNMT inhibitor it is studied for its effects on the NAD+ salvage and methylation cycles

Without adequate B12, nerves can become damaged, leading to symptoms such as numbness, tingling, burning pain, and weakness

IVDD, intervertebral disc degeneration

The Medical Ethical Committee of the AMC provided a letter of no objection to perform the study as formal consent of patients is not required in the Netherlands for retrospective studies

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