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References Centers for Disease Control and Prevention

Since the mechanism of induction of tumours by acetaldehyde has not been well studied, lifetime cancer risk has also been estimated on the basis of a default model (i.e., linearized multistage) (WHO, in press)

Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

Lipoic acid is covalently bound to certain proteins, which function as part of essential mitochondrial multienzyme complexes involved in energy and amino acid metabolism (see Biological Activities)

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These entities have been associated with a variety of detrimental health effects, including cellular apoptosis, inflammation, exacerbation of asthmatic symptoms, fibrosis, chronic lung diseases marked by persistent inflammation, and carcinogenic processes