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doi: 80200 10.8023390/biology8020023

For individuals with severe B12 deficiency (especially those with anaemia or neurological symptoms), some might start to feel an improvement in their energy levels within a few days to a week

The lack of GSH detection can be explained by the possibility that free GSH is maintained in apoplast at a minimum level and is transported back to cytosol after GSSG is reduced

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In terms of causation, the contribution of insufficient vitamin B 12 metabolism to the onset and progression of unrelated disorders such as Parkinson's and Alzheimer's diseases and other dementias awaits the implementation of large population clinical trials

Featherstone DE (2010) Intercellular glutamate signaling in the nervous system and beyond