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COMT is involved in the inactivation of catecholamine neurotransmitters such as epinephrine, norepinephrine, and dopamine, but also catecholestrogens and catechol drugs such as the antiParkinsons disease agent LDOPA and the antihypertensive methyldopa (Weinshilboum et al., 1999)

This ensures the matrix is properly cleared before new collagen and elastin are laid down

Therapeutic interventions in the vicious cycle of oxidative stress and neuroinflammation could offer a promising method for treating neurodegenerative diseases

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