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The underlying mechanism involves the reduction of apoptosis and oxidative stress through the activation of Nrf2 and downstream target genes, showing that exercise-induced cardiac hypertrophy preconditioning may serve as a promising strategy for preventing cardiac fibrosis

Resveratrol activates an enzyme known as sirtuin 1 that plays an important role in the regulation of cellular life spans

Some of the more serious reactions from the central nervous system that were observed with tricyclic antidepressants were noted in short-term studies using cyclobenzaprine for other indications, except for muscle spasm associated with acute disorders of the musculoskeletal system, and mainly in doses, of several higher than those recommended for eliminating skeletal muscle spasm

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Lipid peroxides remain highly reactive, and they or their byproducts propagate free radical generation, leading to protein damage and DNA cross-linking [14, 26]

Alterations in several metabolic pathways are also known to impact resistance to the alkylating agent melphalan