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These mediators include the inflammasome complex NOD-like receptor thermal protein domain associated protein 3 (NLRP3), and tumor necrosis factor-alpha (TNF-), which in turn exacerbate the dendritic and synaptic impairments leading to neuronal death and promote AD progression [13,14,15]

PMID: 16352683 | doi:10.1210/jc.2005-1536 Alba M et al

Schnfeld P, Wojtczak L

Populations exposed to high concentrations of this toxic compound include smokers and second-hand tobacco smokers

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