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GSK is also evaluating the vaccine for use in people 18-49 at increased risk of severe disease, and immunocompromised patients 18 and older

2004 Nov;111(11):1967-80

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doi: 10.1001/archinte.159.4.407

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Hypoxia-induced resistance Immediate effects Hypoxia directly induces the transcription of drug resistance-associated genes, namely MDR1 , MRP1 , and BRCP , which are members of the same ABC transporter family