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Gut dysbiosis, characterized by microbial composition and function alterations, contributes to systemic inflammation and metabolic imbalances, exacerbating CKD progression

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Mice had access to food and water ad libitum, except during the behavioural tests

Additionally, dysfunctional Nrf2 cannot effectively regulate immune responses, leading to the excessive release of inflammatory factors, which worsens joint inflammation and damage

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doi: 10.1111/acel.2015.14.issue-5 Summary Keywords oxidative stress, sperm dysfunction, reactive oxygen species, DNA fragmentation and male infertility, male infertility Citation Wang Y, Fu X and Li H (2025) Mechanisms of oxidative stress-induced sperm dysfunction