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While the exact mechanisms of sleep are still elusive, one theory is that sleep helps wash your brain, and medical experts know that your risk of brain disease increases the more sleep debt you get into

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The existing single-cell RNA sequencing data showed that there are four subgroups in human ICC, including inflammatory subgroup (S1), the highest levels of proteins related to cancer-associated fibroblasts and extracellular matrix subgroup (S2), metabolic subgroup (S3), and maximum expression of adhesion and biliary-specific proteins subgroup (S4) [3]

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