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This makes it a natural choice for researchers transitioning between these two levels or for those on a slower escalation schedule who prefer smaller dose increments

doi: 10.1007/s11032-013-9893-1

AOD-9604 has less-established evidence but fewer known side effects

Periorbital hyperpigmentation can be caused by shallow vascularization or thin skin in the infraorbital region, hyperpigmentation due to atopic or contact dermatitis, familial predisposition, symptomatic tear troughs, localized shadowing from skin laxity, excessive sun exposure, smoking, sleep deprivation, and fatigue (Citation2,Citation8)

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This is experimental territory, and treating it otherwise would be irresponsible