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[DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted] 54

To reverse glutathionylation, glutaredoxin and sulfiredoxin-catalyzed reactions occur, using GSH as a reductant

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These results suggest heme might play a dual role in metastasis, with some studies correlating high heme levels with metastatic potential [48] and others where high heme associated with decreased metastasis in in vivo models [50, 51]